Technology

• NCE
• Biomarkers
• Publications

Publications

• de Medina P., Payré B., Bernad J., Bosser I., Pipy B., Silvente-Poirot S., Favre G., Faye J. C., and Poirot M. Tamoxifen is a Potent Inhibitor of Cholesterol Esterification and Prevents the Formation of Foam Cells. J Pharmacol Exp Ther, 308: 1165-1173, 2004.
  

• Kedjouar B., de Medina P., Oulad-Zegarry M., Payre B., Silvente-Poirot S., Favre G., Faye J. C., and Poirot,M. Molecular characterization of the microsomal tamoxifen binding site. J Biol Chem, 279:34048-34061, 2004.

• de Medina P., Casper C., Savouret J.-F., and Poirot M. Synthesis and Biological properties of new stilbene derivatives as new selective Aryl hydrocarbon Receptor Antagonistic Ligands. J Med Chem, 48, 287-291, 2005.

• de Medina P., Boubekeur N., Balaguer P., Favre G., Silvente-Poirot S., and Poirot M. The Prototypical Inhibitor of Cholesterol Esterification, Sah 58-035 [3-[Decyldimethylsilyl]-N-[2-(4-methylphenyl)-1-phenylethyl]propanamide], Is an Agonist of Estrogen Receptors. J Pharmacol Exp Ther, 319(1) 139-149, 2006.
• Paillasse MR., Deraeve C., de Medina P., Mhamdi L., Favre G., Poirot M., and Silvente-Poirot S. Insights into the cholecystokinin 2 receptor binding site and processes of activation. Mol Pharmacol, 70(6) 1935-1945, 2006. 
• Payré B., de Medina P., Boubekeur N., Mhamdi L., Bertrand-Michel J., Tercé F., Fourquaux I., Goudounèche D., Record M., Poirot M., Silvente-Poirot S. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism. Mol Cancer Ther, 7(12):3707-18, 2008.
• de Medina P, Silvente-Poirot S, Poirot M. Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation. Autophagy, 5(7) :1066-1067, oct. 2009.
• de Medina P, Payré B, Boubekeur N, Bertrand-Michel J, Tercé F, Silvente-Poirot S, Poirot M.  Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism. Cell Death Differ, 16(10):1372-84, oct. 2009.
• Paillasse MR, de Medina P, Amouroux G, Mhamdi L, Poirot M, Silvente-Poirot S. Signaling through cholesterol esterification: a new pathway for the cholescystokinin 2 receptor involved in cell growth and invasion. J Lipid Res, 50(11):2203-2211, nov. 2009.
• de Medina P, Paillasse MR, Payré B, Silvente-Poirot S, Poirot M. Synthesis of new alkylaminooxysterols with potent cell differentiating activities : identification of leads for the treatment of cancer and neurodegenerative diseases. J Med Chem, 52, 7765-7777, dec. 2009.
• Science-Business eXchange 2, (Published online Oct. 1 2009) - SciBX 2(38); doi:10.1038/scibx.2009.1451 Distillery: Therapeutics - http://www.nature.com/scibx/journal/v2/n38/full/scibx.2009.1451.pdf

Abstracts

• de Medina, P., Khallouki, F., Paillasse, M. R., Balaguer, P., Silvente-Poirot, S., and Poirot, M. Vitamin E components are more than antioxidants: they are phyto-estrogens. AACR Meeting Abstracts, 2008: 612, 2008.

• Payre, B., de Medina, P., Boubekeur, N., Bertrand-Michel, J., Terce, F., Silvente-Poirot, S., and Poirot, M. Tamoxifen induces differentiation of human breast cancer cells through an antiestrogen binding site (AEBS) related mechanism. AACR Meeting Abstracts, 2007: 4750-, 2007.

• Poirot, M. E., de Medina, P., Boubekeur, N., Payre, B., Favre, G., and Silvente-Poirot, S. The dendrogenine A: a new aminosteroid for the immunotherapy of cancers. AACR Meeting Abstracts, 2006: 1305-, 2006.

• de Medina, P., Payre, B., Boubekeur, N., Favre, G., Silvente-Poirot, S., and Poirot, M. E. Tamoxifen and (4-benzyl-phenoxy)-ethyl-N-pyrrolidine (PBPE), a selective ligand of the microsomal antiestrogen binding site (AEBS) induced type II apoptosis or autophagy in tumor cell lines. AACR Meeting Abstracts, 2006: 1297-a-, 2006.

• de Medina, P., Bosser, I., Favre, G., Silvente-Poirot, S., and Poirot, M. E. Identification and characterization of the cholesterol epoxide hydrolase. Faseb Journal, 19: A285-A285, 2005.